Publications TACTIC

  1. Adhikari, B., K. Schneider, M. Diebold, C. Sotriffer, and E. Wolf, Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA). Elife, 2024. 13:  PubMed

  2. Kramer, A. and S. Knapp, Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours. Signal Transduct Target Ther, 2024. 9(1): p. 224. PubMed

  3. Vogt, M., N. Dudvarski Stankovic, Y. Cruz Garcia, J. Hofstetter, K. Schneider, F. Kuybu, T. Hauck, B. Adhikari, A. Hamann, Y. Rocca, L. Grysczyk, B. Martin, A. Gebhardt-Wolf, A. Wiegering, M. Diefenbacher, G. Gasteiger, S. Knapp, D. Saur, M. Eilers, M. Rosenfeldt, F. Erhard, S.M. Vos, and E. Wolf, Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2. Gut, 2024. 73(9): p. 1509-1528.PubMed

  4. Sflakidou, E., B. Adhikari, C. Siokatas, E. Wolf, and V. Sarli, Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacol Transl Sci, 2024. 7(11): p. 3488-3501.PubMed

  5. Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Muller S, Knapp S, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, and Halabelian L (2025). Enantioselective Protein Affinity Selection Mass Spectrometry (EAS-MS). bioRxiv.PubMed

  6. Funk JS, Klimovich M, Drangenstein D, Pielhoop O, Hunold P, Borowek A, Noeparast M, Pavlakis E, Neumann M, Balourdas DI, Kochhan K, Merle N, Bullwinkel I, Wanzel M, Elmshauser S, Teply-Szymanski J, Nist A, Procida T, Bartkuhn M, Humpert K, Mernberger M, Savai R, Soussi T, Joerger AC, and Stiewe T (2025). Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. Nat Genet 57: 140-153.PubMed

  7. Schulz T, Gontla R, Teuber A, Beerbaum M, Fletcher BS, Muhlenberg T, Kaitsiotou H, Hardick J, Jeyakumar K, Keul M, Muller MP, Sievers S, Bauer S, and Rauh D (2025). Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors horizontal line Exploring Their Potential in Targeting GIST. J Med Chem 68: 3238-3259.PubMed

  8. Moyano PM, Kubina T, Paruch SO, Jaroskova A, Novotny J, Skockova V, Ovesna P, Suchankova T, Prokofeva P, Kuster B, Smida M, Chaikuad A, Kramer A, Knapp S, Soucek K, and Paruch K (2025). Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Angew Chem Int Ed Engl 64: e202412786.PubMed

  9. Miletic N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Muller J, Adhikari B, Nemec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Muller S, Kuster B, Wolf E, Dikic I, and Knapp S (2025). Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol 20: 507-521.PubMed

  10. Haag A, Nemec V, Janovska P, Bartosikova J, Adhikari B, Muller J, Schwalm MP, Cada S, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, and Knapp S (2025). Development and Discovery of a Selective Degrader of Casein Kinases 1 delta/epsilon. J Med Chem 68: 506-530.PubMed

  11. Pieper NM, Schnell J, Bruecher D, Knapp S, and Vogler M (2024). Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFkappaB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC. Cell Commun Signal 22: 415.PubMed

  12. Zhu WF, Franz HM, Kramer A, Duman E, Empel C, Gobel MW, Koenigs RM, Knapp S, Hiesinger K, Proschak E, and Hernandez-Olmos V (2024). Oxadiazolone-Based Aromatic Annulations: A Nitrenoid Precursor for Tricyclic Aminoheterocycles. J Org Chem 89: 15542-15552.PubMed

  13. Pranjali Bhandare , Ashwin Narain, Julia Hofstetter, Teresa Rummel, Julia Wenzel, Christina Schülein-Völk , Stephanie Lamer , Ursula Eilers, Andreas Schlosser, Martin Eilers, Florian Erhard, Elmar Wolf (2025). Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.PubMed